Table 2 Odds ratios for ALS by quartiles of serum IGF-1 concentrations.

	Odds ratio (95%-CI)
Crude (N_Cases = 294, N_Controls = 504)^a
Bottom quartile (<80.8 ng/ml)	(ref.) 1.00
2^nd quartile (80.8 –<99.9 ng/ml)	0.91 (0.60, 1.38)
3^rd quartile (99.9 –<121 ng/ml)	1.06 (0.70, 1.60)
Top quartile (≥121 ng/ml)	0.96 (0.63, 1.45)
p-value for trend	0.97
Adjusted (N_Cases = 277, N_Controls = 494)^b
Bottom quartile (<80.8 ng/ml)	(ref.) 1.00
2^nd quartile (80.8 –<99.9 ng/ml)	0.93 (0.60, 1.42)
3^rd quartile (99.9 –<121 ng/ml)	1.09 (0.71, 1.69)
Top quartile (≥121 ng/ml)	1.09 (0.71, 1.67)
p-value for trend	0.56
Add. adj. for diabetes and BMI (N_Cases = 260, N_Controls = 464)^c
Bottom quartile (<80.8 ng/ml)	(ref.) 1.00
2^nd quartile (80.8 –<99.9 ng/ml)	0.91 (0.57, 1.45)
3^rd quartile (99.9 –<121 ng/ml)	1.02 (0.64, 1.62)
Top quartile (≥121 mg/l)	1.12 (0.71, 1.77)
p-value for trend	0.53
75- < 90^th percentile (121- > 140 ng/ml)	0.94 (0.54–1.62)
90^th (percentile ≥140 ng/ml)	1.38 (0.79, 2.43)

^aControlled for age and sex. ^bAdditionally adjusted for school education, occupational work intensity, smoking (ever) and family history of ALS. ^cAs ^bbut additionally adjusted for diabetes, body mass index (BMI), and time since last meal.

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