Table 4 Hazard ratio by quartiles of serum IGF-1 concentrations among ALS patients.

From: Association of Insulin-like Growth Factor 1 Concentrations with Risk for and Prognosis of Amyotrophic Lateral Sclerosis – Results from the ALS Registry Swabia

 

Hazard ratio (95%-CI)

Crude (NDeceased = 243, NSurvived = 50)a

  Bottom quartile (<80.8 ng/ml)

(ref.) 1.00

  2nd quartile (80.8 -<99.9 ng/ml l)

1.29 (0.90, 1.85)

  3rd quartile (99.9 -<121 ng/ml)

1.17 (0.82, 1.66)

  Top quartile (≥121 ng/ml)

0.97 (0.67, 1.40)

  p-value for trend

0.78

Adjusted (NDeceased = 242, NSurvived = 50)b

  Bottom quartile (<80.8 ng/ml)

(ref.) 1.00

  2nd quartile (80.8 –<99.9 ng/ml)

1.13 (0.78, 1.64)

  3rd quartile (99.9 –<121 ng/ml)

1.22 (0.84, 1.76)

  Top quartile (≥121 ng/ml)

0.90 (0.61, 1.31)

p-value for trend

0.66

  75– < 90th percentile (121->140 ng/ml)

0.87 (0.54, 1.40)

  90th percentile (≥140 ng/ml)

0.93 (0.58, 1.48)

  1. aControlled for age and sex. bAdditionally adjusted for diagnostic delay, site of onset, ALS-FRS and body mass index.
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