Table 1 Active pathways in asthmatic HBECs compared to healthy HBEC at baseline.
From: Mechanical forces induce an asthma gene signature in healthy airway epithelial cells
Pathway | adj. p-valuea (Bonferroni) | genes in pathway | |
|---|---|---|---|
1 | Integrin cell surface interaction | 4.25E-05 | COL4A2, ICAM1, COL4A1, LAMA1, ITGB6, THBS1, TNC, VCAM1, FN1 |
2 | Cytokine- cytokine- receptor interaction | 1.70E-04 | CXCL8, IL1B, CCL2, TNFRSF9, CXCL3, CXCL5, IL6, IFNE, TNFSF14, TNFSF15, CSF1, BMP2, TNFRSF10C, CCL20 |
3 | Class A1 Rhodopsin receptor interaction | 4.74E-03 | CCL2, CXCL3, CXCL8, HTR7, S1PR1, AGT, EDNRA, MTNR1A, GPR68, CXCL5, S1PR3, NPBWR1, CCL20 |
4 | Platelet amyloid precursor protein pathway | 6.39E-03 | SERPINE1, COL4A2, PLAT, COL4A1 |
5 | ECM receptor interaction | 1.18E-02 | COL4A2, FN1, COL4A1, LAMA1, ITGB6, THBS1, TNC |
6 | Extracellular matrix organization | 1.49E-02 | COL4A2, COL4A1, MMP2, TLL2, MMP7, MMP17, COL22A1 |
7 | local acute inflammatory response pathway | 1.49E-02 | VCAM1, CXCL8, ICAM1, IL6 |
8 | Transport of glucose and other sugars, bile, salts, acids, metal ion, and amine compounds | 1.73E-02 | SLC22A3, SLC13A5, SLC39A8, SLC2A3, RHCG, SLC39A2, SLC6A12 |
9 | GPCR ligand binding | 2.24E-02 | CCL2, CXCL3, CXCL8, HTR7, S1PR1, AGT, ENDRA, FZD7, MTNR1A, GPR68, CXCL5, S1PR3, NPBWR1, CCL20 |
10 | Cartilage oligomeric matrix protein pathway | 3.99E-02 | C1S, C1R, CFB, C4A |
