Table 4 Pathways enriched after compressive stress. (24 h).
From: Mechanical forces induce an asthma gene signature in healthy airway epithelial cells
Pathway | adj. p-valuea | genes in pathway | |
|---|---|---|---|
1 | Extracellular matrix organization | 6.03E-11 | COL4A3, COL4A2, COL16A1, MMP3, COL4A1, MMP11, MMP13, COL4A4, COL1A1, MMP2, MMP10, COL5A2, COL8A2, COL7A1 |
2 | Focal adhesion | 2.30E-09 | COL4A2, CAV1, COMP, COL4A1, ITGB3, ITGB6, ITGA9, PDGFB, THBS1, TNC, COL1A1, COL4A4, PDGFD, MYL9, JUN, COL5A2, ITGA4, ACTN1 |
3 | ECM receptor interaction | 5.84E-09 | COL4A2, COL4A4, COMP, COL4A1, ITGB3, ITGA9, ITGB6, THBS1, TNC, COL1A1, COL5A2, ITGA4, |
4 | Integrin cell surface interaction | 3.53E-07 | COL4A3, COL4A2, COL4A4, COL4A1, ITGB3, ITGA9, ITGB6, THBS1, TNC, COL1A1 |
5 | TGFbeta pathway | 7.88E-07 | SMAD7, LTBP1, COMP, THBS1, INHBA, BMP6, BMP7, TGFB2, CDKN2B, FST |
6 | Cytokine- cytokine- receptor interaction | 9.01E-07 | CXCL8, CXCR2, KIT, TNFSF13B, IL11, INHBA, TNFSF9, PDGFB, IL6R, TNFSF14, CXCR4, CXCL14, BMP7, LIF, TGFB2, NGFR, GHR |
7 | PDGF pathway | 1.88E-05 | COL4A3, COL4A2, COL4A4, COL4A1, PDGFB, THBS1, COL1A1, PDGFD, COL5A2, CAMK4, |
8 | Kinesins | 2.72E-05 | KIF4A, KIF15, KIF2C, KIF11, KIFC1 |
