Figure 3
From: The Role of Peripheral Opioid Receptors in Triggering Heroin-induced Brain Hypoxia
Mean (±SEM) changes in heroin-induced temperature responses in the NAc, temporal muscle and skin following sc injections of saline (A, control), naloxone-HCl (B, 0.2 mg/kg), and naloxone-MET (C, 2 mg/kg). Values significantly different from baseline are shown as filled symbols; n indicates the number of averaged tests. Vertical dotted lines with arrows show the moment of injections and horizontal doted lines show baselines. Right panels with bar graphs show the strength of NAc temperature changes calculated as the area under the curve for 100 min post-injection (interval for NAc temperature increase in control); the values represent averaged temperature increase induced by heroin before and after the administration of each testing drug. Asterisks show significant differences vs. the first heroin injection before administration of each testing drug. Second graphs in each row show temperature responses following sc injection of testing drugs (saline and two naloxone analogs).
