Figure 4
From: The Role of Peripheral Opioid Receptors in Triggering Heroin-induced Brain Hypoxia
Mean (±SEM) changes in heroin-induced NAc oxygen responses following sc injections of naloxone-MET (0.24 mg/kg) in freely moving rats. Values significantly different from baseline are shown as filled symbols; n indicates the number of averaged tests. Vertical dotted lines with black arrows show the moments of iv heroin injections and horizontal doted lines show baselines. Right panel with bar graph show the strength of immediate changes in NAc oxygen calculated as the area under the curve (interval used was determined by time of decrease of first heroin injection within session); the values represent oxygen decrease (change below 100%) or increase (above 100%) induced by heroin before and after the administration of naloxone-MET. Asterisks show significant differences vs. the first heroin injection before administration of testing drug. Second graph show NAc oxygen response following sc injection of naloxone-MET.
