Figure 5
From: The Role of Peripheral Opioid Receptors in Triggering Heroin-induced Brain Hypoxia

Rapid changes in NAc oxygen levels in rats induced by iv heroin, shown before and after naloxone-MET administration. Data are shown as the mean±SEM in percent vs. baseline ( = 100%). Filled symbols represent values significantly different from pre-injection baseline. Before naloxone-MET injection was 120 min prior to naloxone-MET injection. After naloxone-MET injection was 30 min after naloxone-MET injection. Black horizontal line shows the time interval, during which there were significant differences between the two curves.