Table 1 Pathways enriched with common variation associated with schizophrenia with putative clinical actionability.
From: Pharmacological enrichment of polygenic risk for precision medicine in complex disorders
Pathway | P threshold (PT) | P value |
|---|---|---|
NOS1 pathway | All SNPs | 6.3 × 10−4 |
Regulation of insulin secretion | P < 0.5 | 3.9 × 10−4 |
CRMPs in Sema3A signalling | P < 0.5 | 9.4 × 10−4 |
GABA synthesis, release, reuptake and degradation | P < 0.5 | 5.8 × 10−4 |
One carbon pool by folate | P < 0.05 | 1.4 × 10−4 |
Hedgehog signalling | P < 0.05 | 1.9 × 10−4 |
HIF-2 pathway | P < 0.005 | 3.1 × 10−5 |
Acetylcholine binding and downstream events | P < 0.005 | 3.8 × 10−4 |
