Table 2 The top enriched drug target for each pharmagenic enrichment score pathway with at least three interacting genes after multiple testing correction.
From: Pharmacological enrichment of polygenic risk for precision medicine in complex disorders
Pathway | Top Drug | Overlap | Adjusted P-value | ATC Code |
|---|---|---|---|---|
NOS1 | Milnacipran | 5 | 1.63 × 10−7 | Other antidepressants |
GABA | Temazepam | 14 | 0 | Benzodiazepine derivatives |
Insulin | Clodronic acid | 3 | 1.97 × 10−3 | Bisphosphonates |
HIF-2 | Ascorbic acid (Vitamin C) | 3 | 4.61 × 10−2 | Ascorbic acid (Vitamin C) |
Acetylcholine | Nicotine | 11 | 0 | Drugs used in nicotine dependence |
Folate | Tetrahydrofolic acid | 11 | 0 | Folic acid and derivatives |
