Table 2 Activation and inactivation parameters of INa. Parameters of the Boltzman fits to the activation and inactivation curves. Each individual cell was fit with a single (activation) or double (inactivation) Boltzman function and the indicated parameters pooled for statistical comparison using Student’s independent t-test. V50 act is the midpoint at which 50% of the channels were activated. V50 inact are the midpoints for the two components of the inactivation curve. *denotes statistically significant difference, p < 0.05.
From: Jedi-1 deficiency increases sensory neuron excitability through a non-cell autonomous mechanism
Activation | WT (n = 8) | KO (n = 7) | |
|---|---|---|---|
V50 act (mV) | −12.8 (SD 4.4) | −17.5 (SD 7.4) | p = 0.15 |
Slope (activation) (mV) | 9.6 (SD 1.4) | 8.5 (SD 2.4) | p = 0.29 |
Inactivation | WT (n = 10) | KO (n = 10) | |
V50 inact 1 (mV) | −68 (SD 13.5) | −70 (SD 10.7) | p = 0.77 |
V50 inact 2 (mV) | −38 (SD 7.8) | −33 (SD 10.1) | p = 0.24 |
Slope inact 1 (mV) | 13.5 (SD 6.3) | 15 (SD 7.8) | p = 0.69 |
Slope inact 2 (mV) | 5.4 (SD 1.1) | 5.6 (SD 1.6) | p = 0.71 |
Fractional contribution of component 1 | 0.17 (SD 0.17) | 0.39 (SD 0.27) | *p = 0.046 |
