Table 1 Results for newly identified and previously reported risk variants associated with uterine leiomyoma at P < 6.6 × 10−9 in Japanese populations.
From: Identification of a novel uterine leiomyoma GWAS locus in a Japanese population
SNP | Locus | Nearest Gene | Non Reference Allele | Reference Allele | GWAS Screening Stage 1 | Screening Stage 2 | Replication stage | Combined | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR | 95% CI | P | OR | 95% CI | P | OR | 95% CI | P | OR | 95% CI | P | Heterogeneity | ||||||
Qa | I2 b | |||||||||||||||||
Newly Identified Locus | ||||||||||||||||||
rs17033114 | 12q23.2 | LINC00485 | T | C | 1.147 | 1.084-1.214 | 2.62E-06 | 1.185 | 1.135-1.237 | 2.25E-14 | 1.200 | 1.118-1.288 | 4.52E-07 | 1.177 | 1.141-1.213 | 6.12E-25 | 0.556 | 0.000 |
Reported Loci | ||||||||||||||||||
rs3820282 | 1p36.12 | WNT4 | C | T | 0.854 | 0.816-0.893 | 3.19E-12 | 0.853 | 0.825-0.882 | 5.42E-20 | 0.870 | 0.817-0.927 | 1.58E-05 | 0.856 | 0.835-0.877 | 3.49E-35 | 0.856 | 0.000 |
rs12479436 | 2p25.1 | GREB1 | G | T | 1.094 | 1.046-1.144 | 6.45E-05 | 1.144 | 1.107-1.183 | 5.06E-15 | 1.072 | 1.006-1.141 | 3.09E-02 | 1.118 | 1.090-1.145 | 9.50E-19 | 0.109 | 54.970 |
rs2251795 | 3q26.2 | MYNN | A | T | 0.882 | 0.843-0.923 | 5.89E-08 | 0.910 | 0.878-0.943 | 9.08E-08 | 0.933 | 0.874-0.996 | 3.83E-02 | 0.904 | 0.882-0.928 | 1.24E-14 | 0.333 | 8.950 |
rs2242652 | 5p15.33 | TERT | G | A | 0.891 | 0.847-0.938 | 1.03E-05 | 0.900 | 0.865-0.936 | 1.70E-07 | 0.885 | 0.823-0.952 | 9.64E-04 | 0.895 | 0.870-0.921 | 2.42E-14 | 0.905 | 0.000 |
rs75228775 | 10q24.33 | SLK | C | T | 0.755 | 0.698-0.817 | 1.28E-12 | 0.751 | 0.708-0.796 | 2.98E-21 | 0.813 | 0.726-0.910 | 3.22E-04 | 0.761 | 0.729-0.795 | 7.45E-35 | 0.465 | 0.000 |
rs2280543 | 11p15.5 | SIRT3 | C | T | 1.393 | 1.296-1.498 | 3.99E-19 | 1.337 | 1.266-1.412 | 2.15E-25 | 1.279 | 1.157-1.414 | 1.54E-06 | 1.344 | 1.296-1.394 | 2.05E-47 | 0.384 | 0.000 |
rs7989971 | 13q14.11 | FLJ42392 | C | G | 1.122 | 1.073-1.174 | 5.14E-07 | 1.067 | 1.030-1.105 | 2.23E-04 | 1.071 | 1.005-1.140 | 3.39E-02 | 1.085 | 1.058-1.113 | 3.33E-10 | 0.207 | 36.590 |
rs12484776 | 22q13.1 | TNRC6B | A | G | 0.837 | 0.800-0.876 | 4.16E-15 | 0.937 | 0.905-0.971 | 2.11E-04 | 0.870 | 0.816-0.927 | 2.03E-05 | 0.893 | 0.871-0.916 | 4.63E-18 | 0.000 | 87.260 |
