Figure 4 | Scientific Reports

Figure 4

From: Expression of L-type amino acid transporter 1 as a molecular target for prognostic and therapeutic indicators in bladder carcinoma

Figure 4

Association between LAT1 and IGFBP-5 expression. The expression of IGFBP-5 in T24 and 5637 cells were inhibited by siLAT1(A and B). Knocked down the expression of LAT1 inhibited expression of IGFBP-5, phosphorylation of AKT, 4EBP-1 and p70s6k (C and D). Knocked down the expression of IGFBP-5 in T24 and 5637 cells using siIGFBP-5(E and F), did not affect the expression of LAT1 in mRNA levels (G and H) and protein levels (I and J). Nega indicates negative siRNA control. Data represent three independent experiments with similar results. P-values were calculated by the Mann–Whitney U-test. N.S., no significant difference. *P < 0.05, **P < 0.01, ***P < 0.001.

Back to article page