Figure 4
Boxplots represent fusion transcripts are enriched in adult brain compared to the fetal brain. (a) In case of single cells, adult neurons (red) harbor significantly higher number of fusions with respect to fetal neurons (blue) (one tailed Wilcoxon p value < 10−4 is marked by ***). (b) Similarly, bulk tissue from adult brain (red) also demonstrated higher number of fusions compared to fetal (blue) (one tailed Wilcoxon p value < 10−3 is marked by **) where horizontal axis denotes brain samples while vertical axis represents number of fusion transcripts normalized with total data generated in a samples. Pathway enrichment analysis of genes harboring fusions has revealed enrichment for genes implicated in processes involved in synaptic plasticity. In the figure the horizontal axis shows the negative logarithm of FDR corrected p-value while vertical axis has different biological processes. Top biological processes that were significantly enriched in adult brain (c) and fetal brain (d) (both from tissue and single cells).
