Figure 4 | Scientific Reports

Figure 4

From: Amine oxidase 3 is a novel pro-inflammatory marker of oxidative stress in peritoneal endometriosis lesions

Figure 4

Hemoglobin, iron overload, ROS production and lipid peroxidation in ectopic lesions. (A,B) Immunohistochemistry staining of ectopic lesions showing (A) haptoglobin expression, (B) infiltrating CD68+ macrophages in a typical lesion. (C) Ranking plot of top 100 expressed transcripts derived from RNAseq of peritoneal macrophages of endometriosis patients. Red bars indicate transcripts involved in iron/heme metabolism, green bars display housekeeping genes such as beta-actin (ACTB) and GAPDH. (D) Immunohistochemistry of AOC3 in ectopic lesions. (E,F) Co-localisation studies of alkenal reductase PTGR1 (E) and methionine sulfoxide reductase MSRB3 (F) (both pink) in comparison to infiltrating macrophages (CD68 green, CD163 red). Popo1 staining is used to highlight nuclei.

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