Table 1 Demographic data and percentage of resPrP^D T2 detected in the brain of sCJDVV1, sCJDVV2 and sCJDVV1-2.

sCJD subtype	Case #	Disease onset^a	Disease duration^a	% resPrP^D T2^b
sCJD subtype	Case #	Disease onset^a	Disease duration^a	Cerebral cortex^a,c	Subcortical regions^a,d	Cerebellum^a	Whole brain^a,e
VV2	1-8	68 ± 8^f	6 ± 2^f	100	100	100	100
VV1-2	1	55	4	97	100	100	98
	2	70	3	100	100	76	98
	3	70	17	94	97	100	96
	4	66	4	93	99	100	95
	5	74	5	90	99	100	93
	6	73	7	100	62	100	93
	7	44	7	88	99	99	92
	8	45	5	87	100	100	91
	9	57	8	69	93	100	77
	10	60	5	63	87	100	72
	11	79	8	48	91	100	63
	12	84	4	45	73	100	55
	13	60	5	38	78	64	48
	14	68	4	26	45	100	37
	15	69	26	2	28	0	9
	16	71	18	6	10	10	8
	17	66	3	9	1	ND	7
	18	52	7	4	5	ND	4
		65 ± 11^f	8 ± 6^f	59 ± 37^f	70 ± 36^f	84 ± 33^f	65 ± 41^f
VV1	1-5	32 ± 5^f	11 ± 2^f	0	0	0	0

^aExpressed as individual numerical values or means ± SD. ^bAll T2% values determined by densitometry on long gels WB probed with Ab 3F4 and 1E4. ^cAverage of frontal (superior and middle gyrus), temporal, parietal, occipital (visual and non-visual), entorhinal and hippocampal cortices. ^dAverage of putamen, thalamus and substantia nigra. ^eAverage of previous three brain regions. ^fExpressed as mean ± standard deviation. ND: Neither T1 nor T2 were detected.

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