Table 3 Estimated mean rates of reduction in the ganglion cell-inner plexiform layer thickness: results from linear mixed models.

From: Ganglion Cell – Inner Plexiform Layer Damage in Diabetic Patients: 3-Year Prospective, Longitudinal, Observational Study

 

Control (μm/year, 95% CI)

p-value

No-DR (μm/year, 95% CI)

p-value

NPDR (μm/year, 95% CI)

p-value

p-value * (control vs. no-DR)

p-value * (control vs. NPDR)

p-value * (no-DR vs. NPDR)

Average

−0.277 (−0.445, −0.108)

0.001

−0.627 (−0.779, −0.475)

<0.0001

−0.987 (−1.336, −0.637)

<0.0001

0.010

0.001

0.163

Superior

−0.301 (−0.577, −0.025)

0.033

−0.614 (−0.894, −0.335)

<0.0001

−0.929 (−1.266, −0.592)

<0.0001

0.126

0.004

0.230

Superotemporal

−0.026 (−0.276, 0.223)

0.834

−0.588 (−0.771, −0.405)

<0.0001

−0.806 (−1.181, −0.432)

<0.0001

0.001

0.0005

0.452

Inferotemporal

−0.308 (−0.641, 0.025)

0.070

−0.593 (−0.769, −0.417)

<0.0001

−0.899 (−1.238, −0.561)

<0.0001

0.196

0.009

0.224

Inferior

−0.416 (−0.824, −0.009)

0.045

−0.573 (−0.834, −0.312)

<0.0001

−1.039 (−1.479, −0.599)

<0.0001

0.614

0.034

0.151

Inferonasal

−0.352 (−0.605, −0.099)

0.007

−0.719 (−0.889, −0.550)

<0.0001

−1.047 (−1.484, −0.610)

<0.0001

0.032

0.007

0.300

Superonasal

−0.269 (−0.587, 0.049)

0.097

−0.700 (−0.902, −0.498)

<0.0001

−1.161 (−1.614, −0.709)

<0.0001

0.042

0.001

0.163

  1. DR = diabetic retinopathy; NPDR = nonproliferative DR; CI = confidence interval.
  2. *p-value for between-group differences and the follow-up duration based on linear mixed models.
  3. Significant differences are in bold font.