Figure 1
From: Parathyroid hormone receptor 1 (PTHR1) is a prognostic indicator in canine osteosarcoma
Immunohistochemical staining for PTHR1 and PTHrP in canine OS. Positive and negative cells could be seen in both the tumour and the osteoid areas. (A) Neoplastic cells are characterised by low cytoplasmic plus nuclear immunostaining intensity for PTHR1. (B) Neoplastic cells are characterised by high cytoplasmic plus nuclear immunostaining intensity for PTHR1. (C, D) Non-immune control for the above cases. Neoplastic cells are characterised by absent cytoplasmic or nuclear immunolabelling for PTHR1. (E) Neoplastic cells display low cytoplasmic immunostaining intensity for PTHrP. (F) Neoplastic cells display high cytoplasmic plus nuclear immunostaining intensity for PTHrP. (G, H) Non-immune control for the above cases. Neoplastic cells are characterised by absent cytoplasmic or nuclear immunolabelling for PTHrP. Immunohistochemistry. Mayer’s haematoxylin counterstaining.
