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Figure 1

From: Statin-induced myopathic changes in primary human muscle cells and reversal by a prostaglandin F2 alpha analogue

Figure 1

Gene expression profiling of primary human myotubes exposed to statins. Four primary human myotube cell populations from four different statin naïve donors were left untreated (UT), treated with DMSO, rosuvastatin (Rosu) or simvastatin (Sim). (A) Principal components analysis (PCA) of RNA-Seq samples. The PCA plot shows a clear grouping. (B) Heatmap of RNA-Seq samples represents log2 transformed normalized count data of differently expressed genes. Samples of each statin group cluster hierarchically together. Untreated and DMSO treated samples are equally clustered confirming that DMSO has no significant effect on RNA expression data. (C) Venn diagram displaying overlaps between proteome and transcriptome expression data from simvastatin and rosuvastatin groups. Cell populations C1-C3; C5 used in this experiment, see Supplementary Table S1. See also Supplementary Fig. S1 and Supplementary Dataset Files 1 and 2.

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