Table 2 Enrichment of hypertension by different databases.

From: Human cytomegalovirus promoting endothelial cell proliferation by targeting regulator of G-protein signaling 5 hypermethylation and downregulation

Group

upregulation

downregulation

Control vs HCMV

ADRB3 ACE PTGIS ERAP1

RGS5 NOS3

Control vs HG + ox-LDL

ATP1B1 PTGIS

—

HCMV vs HG + ox-LDL + HCMV

ATP1B1 RGS5

CYBA ERAP1 ADRB2 PTGIS

HG + ox-LDL vs HG + ox-LDL + HCMV

GRK4 ADRB3 ACE ATP1B1

RGS5 PTGIS NEDD4L CYBA ERAP1 ADRB2 NPR2

  1. Note. Adrenoceptor beta 3(ADRB3); Angiotensin-converting enzyme(ACE); Prostaglandin I2 (prostacyclin) synthase (PTGIS); Endoplasmic reticulum aminopeptidase 1(ERAP1); Regulator of G-protein signaling 5(RGS5), Nitric oxide synthase 3(NOS3); ATPase, Na+/K+ transporting, beta 1 polypeptide(ATP1B1); Cytochrome b-245, alpha polypeptide(CYBA); Endoplasmic reticulum aminopeptidase 1(ERAP1); Adrenoceptor beta 2, surface (ADRB2); G protein-coupled receptor kinase 4(GRK4); Neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase (NEDD4L); endoplasmic reticulum aminopeptidase 1 (ERAP1); Adrenoceptor beta 2, surface (ADRB2); Selectin E (SELE); Natriuretic peptide receptor 2(NPR2).
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