Figure 2

PA Echo Parameters. (A) PAT (p = 0.002, n = 8/group) (B). PAT/PET (p = 0.001, n = 8) (C). PA Peak Gradient (p = 0.050, n = 8) (D). PA Mean Velocity (p = 0.038, n = 8) (E). MPAP (Common) (p = 0.004, n = 7) (F). MPAP (PAT < 120 ms) (p = 0.002, n = 8) were all assessed after 24-hrs. (A’) PAT (p = 0.004, n = 7) (B’). PAT/PET (p = 0.001, n = 7) (C’). PA Peak Pressure (p = 0.034, n = 7) (D’). PA Peak Velocity (p = 0.038, n = 7) (E’). MPAP (Common) (p = 0.004, n = 7) (F’). MPAP (PAT < 120 ms) (p = 0.004, n = 7); were assessed after 1-M. (G,H) Bifurcated PA color flow Doppler (representative images) PM and PBS exposed respectively. Color Doppler mode shows flow direction of red (toward the transducer) or blue (away from transducer), with intensity as a function of velocity. (G’,H’) Structure of PA demonstrated by corresponding greyscale images. (I,J and I’,J’) Pulsed-wave Doppler waveforms (representative images) derived from these velocities are shown PM and PBS exposed both at 24-hrs and 1-M, respectively. A notch (yellow arrow) appears during pulmonary ejection time at both 24-hrs and 1-M after PM-exposure that is not seen in PBS. Further, a bidirectional flow pattern appeared at 1-M, indicating a pulmonary valve insufficiency (red arrow). RV Echo Parameters. (K) A-peak of tricuspid valve (p = 0.010, n = 6). (L) E-peak of tricuspid valve (p = 0.010, n = 6). (M) E/A ratio of tricuspid valve (p = 0.016, n = 6). (N) Proximal outflow tract (p = 0.045, n = 4), (O). Stroke Volume (p = 0.237, n = 6) (P). Internal diameter (p = 0.002, n = 5) (Q). Free wall thickness (p = 0.017, n = 5), (R). RV Area (p = 0.003, n = 5). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.