Table 1 Loci associated with a genome-wide significant threshold after the cross-disease meta-analysis of systemic sclerosis and Crohn’s disease.

From: A cross-disease meta-GWAS identifies four new susceptibility loci shared between systemic sclerosis and Crohn’s disease

 

Discovery

Replication

Discovery + Replication

SSc

CD

SSc-CD

SSc

CD

SSc-CD

Region

Gene

SNP

Test Allele

P-value

OR

P-value

OR

P-value

P-value

OR

P-value

OR

P-value

1p31.3

IL12RB2

rs6659932

A

2.47E-08

1.3

1.33E-04

0.79

1.54E-11

3.75E-03

1.13

3.44E-02

0.86

1.08E-11

5q31.1

IRF1

rs2548998

G

1.55E-03

1.27

3.09E-07

0.79

1.13E-08

2.00E-02

1.08

1.18E-03

0.88

2.18E-11

6p21.31

ZBTB9/BAK1

rs68191

C

8.15E-03

0.84

8.70E-06

1.39

8.33E-07

2.09E-04

0.82

1.56E-02

1.15

1.07E-10

17q21.2

STAT3

rs4796791

T

1.34E-03

1.13

1.52E-04

0.84

9.86E-07

3.85E-02

1.08

1.85E-02

0.90

2.52E-08

  1. Results of the discovery and replication analysis for each individual disease and of the combined meta-analysis (discovery + replication) are shown.
  2. SNP, single-nucleotide polymorphism; SSc, systemic sclerosis; CD, Crohn’s disease.
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