Table 2 Most significantly enriched Gene Ontology (GO)-biological processes in the set of genetic risk loci shared between systemic sclerosis and Crohn’s disease.
Biological pathway | GO term | p-value* | Count in gene set | Shared genes involved |
|---|---|---|---|---|
Interleukin-35-mediated signaling pathway | GO:0070757 | 1.44E-05 | 3 of 11 | STAT4, STAT3, IL12RB2 |
Interleukin-23-mediated signaling pathway | GO:0038155 | 1.44E-05 | 3 of 9 | STAT4, STAT3, TYK2 |
Cytokine-mediated signaling pathway | GO:0019221 | 6.16E-05 | 6 of 655 | STAT4, STAT3, IL12RB2, TYK2, IRF1, IRF8 |
Interleukin-12-mediated signaling pathway | GO:0035722 | 3.20E-04 | 3 of 47 | STAT4, IL12RB2, TYK2 |
Type I interferon signaling pathway | GO:0060337 | 3.60E-04 | 3 of 65 | TYK2, IRF1, IRF8 |
Interleukin-21-mediated signaling pathway | GO:0038114 | 6.00E-04 | 2 of 8 | STAT4, STAT3 |
Interleukin-27-mediated signaling pathway | GO:0070106 | 8.30E-04 | 2 of 11 | STAT3, TYK2 |
Positive regulation of transcription by RNA polymerase II | GO:0045944 | 4.90E-03 | 5 of 1104 | STAT4, STAT3, IRF1, IRF8, IKZF3 |
Positive regulation of interleukin-12 production | GO:0032735 | 5.90E-03 | 2 of 34 | IRF1, IRF8 |
Receptor signaling pathway via JAK-STAT | GO:0007259 | 7.90E-03 | 2 of 41 | STAT4, STAT3 |
Alpha-beta T cell differentiation | GO:0046632 | 9.70E-03 | 2 of 50 | STAT3, IRF1 |
