Figure 1

Partial least squares correspondence analysis (PLSCA) between right FFA-MRI (rFFA-MRI) phenotypes and COMT polymorphisms. (A) The first pair of latent variables (LVs) from the PLSCA. Left: weighted saliences and 95% confidence interval for each COMT genotype; right: weighted saliences (weights) and 95% confidence interval for each modal of the rFFA. The rFFA (cluster in red) was defined as a set of contiguous voxels (233 voxels) that were significantly activated in response to faces vs. objects (Z > 2.58, one-tailed, p < 0.005, uncorrected) in the lateral mid- and posterior fusiform gyrus in the right hemisphere. (B) The first partial least squares component (PLS1) identified a profile (linear combination) of COMT genotypes that were positively correlated with face selectivity (FS), negatively correlated with fALFF, and not correlated with GMV of the rFFA.