Table 5 Baseline characteristics of the CHC patients with an SVR with baseline glucose levels ≥ 5.6.

From: Hepatitis C Virus Clearance with Glucose Improvement and Factors Affecting the Glucose Control in Chronic Hepatitis C Patients

Parameters

All (N = 332)

Improved (N = 182)

Unimproved (N = 150)

P - valuea

Male

173(52.1%)

96(52.7%)

77(51.3%)

0.797

Age, years

51(44–61)

49(41–59.25)

54(46.75–62)

0.004b

Genotype

    

1

217(65.4%)

116(63.7%)

101(67.3%)

0.604

2

11(3.3%)

5(2.7%)

6(4%)

 

3

27(8.1%)

14(7.7%)

13(8.7%)

 

Others and unknown

77(23.2%)

47(25.8%)

30(20%)

 

HCV-RNA, log IU/mL

6.07(5.17–6.55)

6.06(4.95–6.56)

6.08(5.31–6.56)

0.460

GLU, mmol/L

6.22(5.84–6.94)

6.05(5.75–6.88)

6.38(5.99–7.62)

<0.001b

Prediabetes

250(75.3%)

139(76.4%)

111(74%)

0.618

Diabetes

82(24.7%)

43(23.6%)

39(26%)

 

TBiL, umol/L

16.65(11.82–21.67)

15.50(12.05–21.22)

17.90(11.70–22.75)

0.190

ALT, IU/L

56.50(33.00–110.75)

56.00(32.00–103.00)

58.00(37.00–123.25)

0.515

AST, IU/L

54.00(33.00–90.00)

52.00(32.75–86.25)

54.50(33.00–92.25)

0.435

ALB, g/L

43.80(40.72–46.60)

43.90(41.00–46.80)

43.60(40.25–46.50)

0.472

ALP, IU/L

85.00(69.00–110.00)

82.00(68.00–105.25)

92.00(71.00–122.25)

0.024b

GGT, IU/L

41.50(26.00–93.25)

42.50(25.75–83.75)

40.50(25.75–96.25)

0.824

Hb, g/L

141.00(126.00–153.00)

141.00(127.00–154.25)

137.50(125.00–153.00)

0.388

PLTs, 109/L

114.00(77.25–153.25)

118.50(84.50–166.50)

108.50(73.00–142.25)

0.014b

WBCs, 109/L

5.24(4.13–6.52)

5.36(4.27–6.59)

4.93(3.91–6.48)

0.118

APRI

1.23(0.65–2.61)

1.05(0.63–2.18)

1.41(0.69–3.04)

0.036b

FIB-4

3.43(1.94–6.01)

3.13(1.81–5.21)

3.93(2.30–7.36)

0.003b

  1. CHC, chronic hepatitis C; SVR, sustained virologic response; HCV RNA, hepatitis C virus ribonucleic acid; FPG, fasting plasma glucose; TBiL, total bilirubin; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALB, albumin; ALP, alkaline phosphatase; GGT, gamma glutamyltranspeptidase; Hb, hemoglobin; PLTs, platelets; WBCs, white blood cells; APRI, aspartate aminotransferase to platelet ratio index; FIB-4, Fibrosis-4. aThe χ2 test or Fisher’s exact probability test was used to examine the categorical variables such as sex, age, genotype and diabetes status, and the Mann-Whitney U test was used to examine the continuous variables between the improved and unimproved group. bValues were statistically significant at P < 0.05.