Table 6 The independent variables that influence the glucose improvement.

From: Hepatitis C Virus Clearance with Glucose Improvement and Factors Affecting the Glucose Control in Chronic Hepatitis C Patients

Parameters

Improved

Unimproved

OR (95%CI)

P - valuea

(N = 182)

(N = 150)

Sex (Ref-male)

96(52.7%)

77(51.3%)

1

 

Female

86(47.3%)

73(48.7%)

0.656(0.325–1.324)

0.239

Age, years (Ref-<44)

54(29.7%)

23(15.3%)

1

 

≥44 and <51

40(22%)

38(25.3%)

2.038(0.921–4.510)

0.079

≥51 and <61

47(25.8%)

43(28.7%)

1.792(0.787–4.082)

0.165

≥61

41(22.5%)

46(30.7%)

2.816(1.217–6.513)

0.016b

Genotype (Ref-1)

157(86.3%)

129(86%)

1

 

2

7(3.8%)

4(2.7%)

1.378(0.408–4.652)

0.605

3

16(8.8%)

11(7.3%)

1.066(0.479–2.375)

0.875

Others and unknown

1(0.5%)

1(0.7%)

0.733(0.431–1.246)

0.251

HCV-RNA, log IU/mL (Ref<5.17)

53(29.1%)

29(19.3%)

1

 

  ≥5.17 and <6.07

39(21.4%)

44(29.3%)

1.848(0.854–3.998)

0.119

  ≥6.07 and <6.55

44(24.2%)

38(25.3%)

2.005(0.888–4.525)

0.094

  ≥6.55

46(25.3%)

39(26%)

2.359(1.061–5.247)

0.035b

FPG, mmol/L (Ref-<5.84)

60(33%)

23(15.3%)

1

 

  ≥5.84 and <6.22

46(25.3%)

37(24.7%)

2.962(1.358–6.464)

0.006b

  ≥6.22 and <6.94

33(18.1%)

50(33.3%)

4.540(2.074–9.941)

<0.001b

  ≥6.94

43(23.7%)

40(26.7%)

3.325(1.479–7.471)

0.004b

TBiL, mmol/L (Ref-<11.82)

43(23.6%)

40(26.7%)

1

 

≥11.82 and <16.65

58(31.9%)

25(16.7%)

1.056(0.364–3.064)

0.921

≥16.65 and <21.67

42(23.1%)

41(27.3%)

3.763(1.027–13.794)

0.046b

≥21.67

39(21.4%)

44(29.3%)

5.010(1.150–21.832)

0.032b

ALT, IU/L (Ref-<33.00)

49(26.9%)

33(22%)

1

 

≥33.0 and <56.50

43(23.6%)

41(27.3%)

1.908(0.735–4.954)

0.184

≥56.50 and <110.75

49(26.9%)

34(22.7%)

1.952(0.663–5.747)

0.224

≥110.75

41(22.5%)

42(28%)

4.468(1.126–17.729)

0.033b

AST, IU/L (Ref-<33.00)

45(24.7%)

33(22%)

1

 

≥33.00 and 54.00

48(26.4%)

39(26%)

0.684(0.259–1.808)

0.444

≥54.00 and 90.00

46(25.3%)

37(24.7%)

0.532(0.164–1.729)

0.294

≥90.00

43(23.6%)

41(27.3%)

0.330(0.067–1.620)

0.172

ALB, g/L (Ref-<40.72)

41(22.5%)

42(28%)

1

 

≥40.72 and <43.80

46(25.3%)

34(22.7%)

0.608(0.276–1.339)

0.217

≥43.80 and <46.60

46(25.3%)

38(25.3%)

0.817(0.365–1.828)

0.622

≥46.60

49(26.9%)

36(24%)

0.651(0.288–1.473)

0.303

ALP, IU/L (Ref-<69.00)

48(26.4%)

34(22.7%)

1

 

≥69.00 and <85.00

52(28.6%)

30(20%)

0.673(0.308–1.471)

0.321

≥85.00 and <110.00

47(25.8%)

36(24%)

1.084(0.501–2.348)

0.838

≥110.00

35(19.2%)

50(33.3%)

2.104(0.863–5.126)

0.102

GGT, IU/L (Ref<26.00)

45(24.7%)

37(24.7%)

1

 

≥26.00 and <41.50

45(24.7%)

39(26%)

0.628(0.286–1.382)

0.248

≥41.50 and <93.25

49(26.9%)

34(22.7%)

0.476(0.196–1.156)

0.101

≥93.25

43(23.6%)

40(26.7%)

0.587(0.211–1.630)

0.306

Hb, g/L (Ref-<26)

42(23.1%)

39(26%)

1

 

≥26 and <141

44(24.2%)

40(26.7%)

1.245(0.570–2.720)

0.582

≥141 and <153

46(25.3%)

31(20.7%)

0.761(0.315–1.837)

0.544

≥153

50(27.5%)

40(26.7%)

1.111(0.407–3.033)

0.838

PLTs, 109/L (Ref<77.25)

35(19.2%)

48(32%)

1

 

≥77.25 and <114.00

50(27.5%)

32(21.3%)

0.553(0.234–1.310)

0.178

≥114.00 and <153.25

42(23.1%)

42(28%)

0.956(0.346–2.644)

0.931

≥153.25

55(30.2%)

28(18.7%)

0.450(0.143–1.420)

0.173

WBCs, 109/L (Ref-<4.132)

38(20.9%)

45(30%)

1

 

≥4.132 and <5.24

48(26.4%)

34(22.7%)

0.487(0.219–1.083)

0.078

≥5.24 and <6.52

49(26.9%)

35(23.3%)

0.440(0.194–0.999)

0.050

≥6.52

47(25.8%)

36(24%)

0.602(0.256–1.413)

0.244

APRI (Ref- ≤ 2)

130(71.4%)

91(60.7%)

  

>2

52(28.6%)

59(39.3%)

0.895(0.337–2.379)

0.824

FIB-4 (Ref- ≤ 3.25)

94(51.6)

61(40.7%)

  

>3.25

88(48.4)

89(59.3%)

1.219(0.481–3.090)

0.676

  1. OR, odds ratio; CI, confidence interval; HCV RNA, hepatitis C virus ribonucleic acid; FPG, fasting plasma glucose; TBiL, total bilirubin; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALB, albumin; ALP, alkaline phosphatase; GGT, gamma glutamyltranspeptidase; Hb, hemoglobin; PLTs, platelets; WBCs, white blood cells; APRI, aspartate aminotransferase to platelet ratio index; FIB-4, Fibrosis-4. aBinary logistic regression was performed. bValues were statistically significant at P < 0.05.