Figure 8

Activation (left panels) and inactivation I-V curves (right panels) (mean of I1 or I2 ± standard error of mean (SEM)) against each V1 excursion before (i) and following (ii) introduction of 2 mM caffeine in the absence (A) or the presence (B) of 10 μM dantrolene. Families of INa records were obtained 2–15 min (ii), 16–25 min (iii), and 26–40 min (iv) after adding 2 mM caffeine.