Figure 6
From: Regulation of bone metabolism by megakaryocytes in a paracrine manner
Micro-computed tomography analyses of the femurs in ovariectomized nude mice. Female nude mice were sham-operated or ovariectomized (OVX) at 9 weeks of age (n = 15 in each group), and conditioned media (CM) of megakaryocytes (MK) or pro-megakaryocytes (pro-MK) was injected via the tail vein once a day from 13 weeks of age for 4 weeks. Mice were then sacrificed for analyses at 17 weeks of age. The same volume of saline was injected in the control group. (a) Body weight before (Pre) and after (Post) the injections. (b) Trabecular bone parameters of the femurs were also measured. BV/TV, bone volume per tissue volume; Tb.Th, trabecular thickness; Tb.N, trabecular number; and Tb.Sp, trabecular separation. Data are presented as mean ± SEM. *P < 0.05 vs. untreated control; #P < 0.05 vs. pro-MK CM. NS, not significant.
