Figure 1
Genetic correlations between HIV-1 acquisition susceptibility and traits tested within the UK Biobank. (A) Correlations performed within LD Hub using the LDSC model to determine genetic correlations between HIV-1 acquisition and 516 heritable traits. The Bonferroni-significant correlations (rg) are displayed in red and delimited by the horizontal line (P = 0.05/516 traits = 8.38 × 10−5). (B) Validation of the Bonferroni-significant findings using SumHer-GC, which is based on the LDAK model, adjusting for genomic control. The correlation values observed for the 14 Bonferroni-significant traits associated with HIV-1 acquisition in the LDSC method were highly concordant with results using the LDAK method (Pearson’s r = 0.98, P = 2.59 × 10−9).
