Figure 3
HIV-1 acquisition genetics significantly overlaps with the expression profile of T-cells and neurons, and correlates with blood levels of CCL17. (A) Top 20 enrichment signals observed for murine non-neuronal cell types. (B) Top 20 enrichment signals observed for murine neuronal cell types. Green indicates significance under a false discovery rate of 10%. (C) Plot showing -log(p) of the association between 35 markers and a polygenic risk score for HIV-1 acquisition. The dashed line indicates Bonferroni significance. (D) Sensitivity analysis revealed that PRS at every PT significantly correlated with CCL17 levels in blood, with the highest significance at PT = 0.061. (E) Correlation between PRS for HIV-1 acquisition (PT = 0.061) adjusted for seven population dimensions, and CCL17 levels adjusted for age, gender, BMI, ethnicity, and smoking status.
