Table 1 Cross-resistant dose-response for the active epi-drugs. Compounds were screened for IC₅₀ against 3D7, K1 and W2 asexual parasite strains using the SYBR Green I-based fluorescence assay. The resistance index (RI; italic) and selectivity index (SI) for each compound is shown. Compounds with SI > 10 are in bold. Results for all compounds are representative of three independent biological replicates with technical triplicates (n = 3, IC₅₀ ± SEM).

0.0117 ± 0.0023

0.007 ± 0.004

0.60

0.0358 ± 0.0032

3.06

0.028 ± 0.006

0.047 ± 0.007

1.68

0.045 ± 0.006

1.61

0.0283 ± 0.0032

0.039 ± 0.005

1.38

0.05 ± 0.01

1.77

0.035 ± 0.013

0.019 ± 0.004

0.54

0.0291 ± 0.0016

0.83

0.078 ± 0.008

0.066 ± 0.008

0.85

0.066 ± 0.005

0.85

0.17 ± 0.01

0.122 ± 0.028

0.72

0.178 ± 0.015

1.05

0.30 ± 0.07

0.40 ± 0.05

1.33

0.27 ± 0.05

0.90

0.32 ± 0.11

0.44 ± 0.10

1.38

0.30 ± 0.04

0.94

0.37 ± 0.08

0.367 ± 0.028

0.99

0.428 ± 0.023

1.16

0.51 ± 0.08

0.29 ± 0.04

0.57

0.53 ± 0.04

1.04

0.51 ± 0.14

0.50 ± 0.07

0.98

0.64 ± 0.15

1.25

0.71 ± 0.12

0.37 ± 0.04

0.52

0.43 ± 0.06

0.61

0.726 ± 0.005

0.2723 ± 0.0032

0.38

0.363 ± 0.030

0.50

0.94 ± 0.04

1.43 ± 0.16

1.52

0.949 ± 0.032

1.01

1.9 ± 0.5

2.4 ± 1.2

1.26

3.25 ± 0.19

1.71

2.3 ± 0.4

4.33 ± 0.32

1.88

4.9 ± 1.2

2.13

2.77 ± 0.18

5.8 ± 0.7

2.09

2.2 ± 0.6

0.79

3.2 ± 0.7

1.9 ± 0.3

0.59

0.77±0.04

0.24

3.7 ± 0.9

4.7 ± 1.2

1.27

2.3 ± 0.6

0.62