Figure 3 | Scientific Reports

Figure 3

From: Single-molecular real-time deep sequencing reveals the dynamics of multi-drug resistant haplotypes and structural variations in the hepatitis C virus genome

Figure 3

Dynamics of haplotype codes before treatment and after treatment failure. (A) Comparison of the haplotypes between #5-DCV/ASV-pre and #5-DCV/ASV-post. Before therapy, “0202012”, resistant to both the NS3 inhibitor and NS5A inhibitor, existed at a frequency of 0.32% (left table). In contrast, the relative abundance of “0202012” increased to 98.86%, with treatment failure (right table). The % in each table represents the percentage for the number of the CCS2 reads in the sample. (B) Comparison of haplotypes between #8-DCV/ASV-pre and #8-DCV/ASV-post. Although haplotype “0202022” was 1.26% and the minor haplotype at pre-treatment, this haplotype was 82.65%, and the major haplotype at treatment failure. The % in each table represents the percentage for the number of the CCS2 reads in the sample.

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