Figure 6 | Scientific Reports

Figure 6

From: Vitis vinifera polyphenols from seedless black fruit act synergistically to suppress hepatotoxicity by targeting necroptosis and pro-fibrotic mediators

Figure 6

Liver morphology and histopathological images confirming the therapeutic potency of VVF1 as an anti-hepatotoxic agent. C, VVF1 and SM groups showing healthy liver (reddish-brown liver color). Congestion (black arrow) in V group and necrosis (green arrows) with dense fibrous bands (red arrows) as well as steatosis with clusters of inflammatory cells (blue arrows) in the CCl4 group (brown liver color with the abnormal white color area “yellow arrow”). No necroinflammation, steatosis, and fibrosis were shown in CCl4-VVF1 and CCl4-SM (with dilated sinusoids), magnification x200. C, control untreated healthy rat group; V, olive oil (vehicle of CCl4)-injected rats; CCl4, CCl4-induced hepatotoxicity group; CCl4-VVF1 and CCl4-SM; the treatment of CCl4-induced hepatotoxicity with VVF1 and SM, respectively; VVF1 and SM, healthy rats were treated with VVF1 and SM, respectively.

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