Figure 3 | Scientific Reports

Figure 3

From: Combined HER3-EGFR score in triple-negative breast cancer provides prognostic and predictive significance superior to individual biomarkers

Figure 3

Top causal network explaining observed gene expression differences. Master regulator TXN is at the hub of the network, controlling upstream regulators of observed gene expression difference, including EGFR. Solid line: direct interaction; broken line: indirect interaction. Orange: Predicted activation; Blue: predicted inhibition. Causal network analysis was conducted using Ingenuity Pathway Analysis tools.

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