Figure 2
From: Two new, near-infrared, fluorescent probes as potential tools for imaging bone repair
The synthesis of α5β1L-CyTE777. (A) Synthesis of CyTE-777 –NHS ester. A carboxyl group was introduced to a solution of the commercially available dye IR-783 to make CyTE-777. (Scheme 1) CyTE-777 carboxylic acid was introduced into a succinimidyl group to form a CyTE-777-succinimidyl ester. (Scheme 2) (B) Cyclic µ5ß1 specific peptide conjugation. Conjugation of CyTE777-succinimidyl ester-CONHS to NH2 of Gly in cGG*CRRETAWAC* was carried out to form α5β1L-CyTE777.
