Figure 2 | Scientific Reports

Figure 2

From: Development of an embedded multimodality imaging platform for onco-pharmacology using a smart anticancer prodrug as an example

Figure 2

Comparisons of modalities: From biophotonics to ultrasounds and photoacoustics. (A) 2 dimensions biophotonics acquisitions (BLI, BLI kinetic and NIRF) are compared to 3D acquisitions from the VEVO system. Here are presented 2D coronal rendering from 3D acquisitions acquired thanks to the stepper motor. Acquisitions for B-Mode, Power Doppler, Contrast, Oxy-Hemo and PA-Mode can easily be merged on black and white image from the camera. (B) Assessment of the differential Targeted Enhancement (dTE), following the destruction of both targeted and non-targeted microbubbles. A higher dTE means a greater microbubbles fixation, so an important VEGRF2 expression. (C) Examples of comparisons that can be performed on the same slice from the same tumor in vivo. In this set of images, we find transverse Power Doppler, Contrast Imaging and Photoacoustic OxyHemo-Mode. Red arrows highlight hypoxic areas corresponding to VEGFR2 expression. (D) Corresponding transverse parametric images from ultrasound molecular imaging showing the VEGFR2 expression as compared signals from microbubbles targeted via an isotype antibody.

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