Figure 3
From: Inhibition of IL-1beta improves Glycaemia in a Mouse Model for Gestational Diabetes
IL-1β is increased in pregnant mice. IL-1β normalized to average of non-pregnant mice measured in afternoon serum of (A) lean (non-pregnant n = 24, pregnant n = 14), (B) oGDM (non-pregnant n = 27, pregnant n = 19), (C) oGH (non-pregnant n = 11, pregnant n = 6). Il1b gene expression measured in uterine tissue from (D) lean (non-pregnant n = 5, pregnant n = 4), (E) oGDM (non-pregnant n = 14, pregnant n = 7), (F) oGH (non-pregnant n = 19, pregnant n = 12) mice. (G) IL-1β protein measured in uterine tissue of oGDM (non-pregnant n = 6, pregnant n = 4) and oGH (non-pregnant n = 11, pregnant n = 7) mice. Relative gene expression of immune cell markers measured in uterine tissue of (H) oGDM (non-pregnant n = 12, pregnant n = 5) and (I) oGH (non-pregnant n = 15, pregnant n = 8) mice. *P < 0.05, **P < 0.01, ****P < 0.0001 ((A–I) Mann-Whitney U test).
