Table 3 Mendelian Randomization Estimates of the Effect of puberty timing (year) on adult sleep duration (category).
From: Age of puberty and Sleep duration: Observational and Mendelian randomization study
Puberty timing | SNPs | Average F statistic | Mendelian Randomization Method | β | 95% Confidence Interval | I2 (p-value for heterogeneity) | MR-Egger intercept (p-value) | Outliers from MR PRESSO | |
|---|---|---|---|---|---|---|---|---|---|
Women | Age of menarche | 203 (P < 5 × 10−8) | 73.2 | IVW with random-effects | 0.020 | 0.006, 0.034 | 46.0% (<0.0001) | 0.0001 (0.95) | rs9972653 rs35935052 |
WM | 0.021 | 0.003, 0.040 | |||||||
MR Egger | 0.020 | −0.018, 0.058 | |||||||
Corrected MR PRESSO | 0.017 | 0.003, 0.030 | |||||||
Tanner stage | 2 (P < 5 × 10−6) | 26 | IVW with random-effects | 0.008 | −0.035, 0.051 | 82.9% (0.02) | NA | NA | |
Men | Age of voice breaking | 4 (P < 5 × 10−8) | 84.5 | IVW with random-effects | 0.015 | −0.035, 0.064 | 57.2% (0.06) | 0.10 (0.425) | NA |
WM | 0.003 | −0.034, 0.04 | |||||||
MR Egger | −0.086 | −0.338, 0.166 | |||||||
Corrected MR PRESSO | 0.015 | −0.035, 0.064 | |||||||
Tanner stage | 1 (P < 5 × 10−6) | 25 | Wald ratio method | 0.005 | −0.037, 0.048 | NA | NA | NA |
