Figure 1 | Scientific Reports

Figure 1

From: Noninvasive imaging of vascular permeability to predict the risk of rupture in abdominal aortic aneurysms using an albumin-binding probe

Figure 1

Experimental setup. (A) For study 1 (longitudinal), a single MRI session was performed after one week (n = 18) with injection of a clinical dose of the albumin-binding probe gadofosveset. After imaging, animals were followed up for up to four weeks with death by aneurysm rupture as endpoint. The aim was to evaluate the potential of gadofosveset to predict aneurysm rupture. (B) In study 2 (week-by-week study), imaging after administration of gadofosveset (0.03 mmol/kg) was performed after 1, 2, 3, and 4 weeks (n = 9 per group) of angiotensin II infusion. Ex vivo analysis (histology, fluorescence immunohistochemistry, ICP-MS and LA-ICP-MS) was performed after the final scan of each week (n = 9 per week) to correlate in vivo with ex vivo results. As control, nine sham-treated ApoE−/− mice were implanted with osmotic minipumps primed with sodium chloride.

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