Figure 3
From: H-Ferritin is essential for macrophages’ capacity to store or detoxify exogenously added iron
Fth1−/− macrophages have decreased production of nitric oxide but normal release of TNFa as compared to Fth1+/+ macrophages. Fth1+/+ (black) and Fth1−/− (grey) BMDM were treated with IFNG plus LPS, for 3 days. (a) Nitrite production was quantified in the supernatant by the Griess assay. (b) The release of TNFa from BMDM was measured by ELISA. The results shown represent the mean + SD of two to six independent cultures per group (two-way ANOVA with Tukey multiple comparisons test; *p < 0.05).
