Table 2 Relative toxicity of FAC and hemin for Fth1+/+ and Fth1−/− BMDM.

From: H-Ferritin is essential for macrophages’ capacity to store or detoxify exogenously added iron

Compound

IC50 ± SD (µM)a

Fth1+/+

Fth1−/−

FAC

26.6 ± 1.2

9.7 ± 1.1

Hemin

150.9 ± 1.1

49.6 ± 1.0

  1. aEach value represents the average ± SD of three to seven independent cultures per condition. IC50 is the concentration that inhibits 50% of macrophage viability after 3 days of incubation with each compound.
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