Figure 4
From: Abrogation of type-I interferon signalling alters the microglial response to Aβ1–42
APPswePS1ΔE9 × IFNAR1−/− exhibit enhanced phagocytosis towards FITC-Aβ1–42, but not the reverse peptide FITC-Aβ42–1. Cells were treated with either FITC conjugated Aβ1–42 or the reverse peptide Aβ42–1 for 1 and 3 hours before being measured by flow cytometry. Representative distributions for each genotype for Aβ1–42 are shown in (a). Measures of percentage of parent and geometric mean are shown for 1–42 in (b). Representative distributions for each genotype for Aβ42–1 are shown in (c). Measures of percentage of parent and geometric mean are shown for 42–1 in (d). Data is displayed as mean ± SEM (****p < 0.0001, **p < 0.01, 2-way ANOVA, Sidak’s multiple comparisons test, wild type vs. IFNAR1−/− vs. APPswePS1ΔE9 vs. APPswePS1ΔE9 × IFNAR1−/−, n = 3–5).
