Figure 5
From: Abrogation of type-I interferon signalling alters the microglial response to Aβ1–42
Aged 9 and 13-month APPswePS1ΔE9 × IFNAR1−/− brains exhibit unaltered Aβ burden compared to APPswePS1ΔE9 mice. Brain sections from 9 and 13-month old APPswePS1ΔE9 and APPswePS1ΔE9 × IFNAR1−/− were stained with anti-Aβ antibodies for automated plaque analysis. Representative hippocampal and cortical sections for each age of APPswePS1ΔE9 and APPswePS1ΔE9 × IFNAR1−/− are shown in (a). Measurements of (b) cortical plaque size, (c) cortical plaque burden and (d) plaques per mm2 are shown. Measurements of hippocampal measures for each are shown in (e) to (g) respectively. Data is displayed as mean ± SEM, n = 3–6). Scale bar = 2 mm.
