Figure 1
From: A Nonpeptide Oxytocin Receptor Agonist for a Durable Relief of Inflammatory Pain
Pharmacological functional profile of LIT-001 on off-targets. (a) LIT-001 structure, physico-chemical properties and potency on target receptors. (b) In vitro agonist and antagonist profiles of LIT-001 on 24 off-target GPCRs. Cellular agonist and antagonist effects of LIT-001 were calculated as a % of control response to a known reference agonist for each target and cellular antagonist. Negative values are non significant in these assay setups. (c) Enzyme and transporter inhibition potency of LIT-001 on selected off-targets. Compound enzyme inhibition effect was calculated as a % inhibition of control enzyme activity. Compound uptake inhibition effect was calculated as a % inhibition of control uptake activity. Data are expressed as the mean value of 2 independent tests.
