Figure 2
From: A Nonpeptide Oxytocin Receptor Agonist for a Durable Relief of Inflammatory Pain

Ten days’ time course of long-term modifications induced by CFA subcutaneous injection. (a) Scheme of the CFA-induced inflammatory pain model (100 μl). (b) Time-course of the CFA-induced edema size (CFA, n = 14; NaCl, n = 18). (c) Time-course of the CFA-induced mechanical (c1) and thermal heat (c2) hyperalgesia (CFA, n = 14; NaCl, n = 18). Data are expressed as mean ± SEM. Asterisks indicate statistical significance (***p < 0.001) using two-way ANOVA followed by Tukey multiple comparisons post-hoc test.