Table 2 Enrichment analysis of DEGs at terminal disease in the fatal dataset.
From: Immune correlates of postexposure vaccine protection against Marburg virus
Enrichment Pathway | Up/Down-Regulation | Metacore Enrichment Type | DEGs | FDR |
|---|---|---|---|---|
Dendritic cell migration | Down | GO Processes | 31 | 5.51E-03 |
TRIF-dependent toll-like receptor signaling pathway | Down | GO Processes | 35 | 7.75E-03 |
Positive regulation of innate immune response | Down | GO Processes | 430 | 1.24E-02 |
Interleukin-12-mediated signaling pathway | Down | GO Processes | 88 | 1.93E-02 |
Response to interleukin-12 | Down | GO Processes | 90 | 2.06E-02 |
Apoptosis and survival_APRIL and BAFF signaling | Down | Pathway Maps | 39 | 2.56E-02 |
Chemotaxis_CXCR4 signaling pathway | Down | Pathway Maps | 34 | 4.88E-02 |
Apoptotic process | Up | GO Processes | 1310 | 1.97E-15 |
Cell death | Up | GO Processes | 1527 | 6.29E-15 |
Response to wounding | Up | GO Processes | 924 | 2.30E-08 |
Response to transforming growth factor beta | Up | GO Processes | 265 | 6.57E-08 |
Regulation of alpha-beta T cell differentiation | Up | GO Processes | 105 | 3.88E-02 |
WNT signaling pathway | Up | GO Processes | 511 | 2.33E-10 |
Protein folding and maturation_POMC processing | Up | Pathway Maps | 30 | 1.46E-05 |
Development_WNT5A signaling | Up | Pathway Maps | 47 | 3.16E-06 |
Immune response_Function of MEF2 in T lymphocytes | Up | Pathway Maps | 51 | 9.54E-04 |
Immune response_IL-6 signaling pathway via JAK/STAT | Up | Pathway Maps | 72 | 1.68E-03 |
Immune response_IL-4 signaling pathway | Up | Pathway Maps | 94 | 4.08E-03 |
Immune response_IL-9 signaling pathway | Up | Pathway Maps | 36 | 2.50E-03 |
Immune response_IL-5 signaling via JAK/STAT | Up | Pathway Maps | 57 | 4.92E-03 |
Immune response_TLR2 and TLR4 signaling pathways | Up | Pathway Maps | 69 | 7.11E-03 |
Immune response_IFN-alpha/beta signaling via MAPKs | Up | Pathway Maps | 77 | 5.77E-03 |
Immune response_CRTH2 signaling in Th2 cells | Up | Pathway Maps | 44 | 1.27E-02 |
Immune response_IFN-alpha/beta signaling via PI3K and NF-kB pathways | Up | Pathway Maps | 94 | 1.38E-02 |
Immune response_CCL2 signaling | Up | Pathway Maps | 54 | 2.55E-02 |
Normal and pathological TGF-beta-mediated regulation of cell proliferation | Up | Pathway Maps | 33 | 4.13E-02 |
Immune response_Inhibitory PD-1 signaling in T cells | Up | Pathway Maps | 53 | 4.17E-02 |
