Table 4 Binding affinity data and ligand interactions shown by possible isolated phytochemicals against porcine pancreatic α-amylase.
No. | Compound | Binding Affinity (α-Amylase) | Interacting residues of PPA. |
|---|---|---|---|
1 | Genistein | −6.6167 | Leu162, Asp197 and Lys200 |
2 | Apigenin | −5.3037 | Trp59, Asp197 and Asp300 |
3 | Apigenin-7-O-diglucuronide | −8.1976 | Glu233, Glu352 and Asp300 |
4 | Vanillic acid | −4.7156 | Glu233 |
5 | Apigenin-C-hexoside-C-hexoside | −8.3671 | Gln61, Ile235 and Leu237 |
6 | Aapigenin-6,8-di-C-pentoside | −7.6610 | Asp197, Lys200, Glu240 and His305 |
7 | Apigenin-C-hexoside-C-pentoside isomer | −7.3434 | Asp197, Lys 200, Glu240, Gly304 |
8 | Acarbose | −9.5683 | Trp59, Gln63, Arg195, Asp197, Lys200, His201, Glu233, Glu240, Asp300, Gly306 |
