Figure 5

Visualization of the differential relationship between acute BDNF change and pre-post change in trained task performance in the COG + PE and PE + COG groups. Scatterplot with individual data points and zero-order correlations between training gains (pre-post change in performance on trained tasks with untrained stimuli) and acute change in BDNF concentrations in response to physical exercise in plasma at pretest (R). A relationship between exercise-induced BDNF change and cognitive training gain only exists in the group that received physical exercise prior to cognitive training (COG + PE, pale blue). Note that the three-way interaction remains significant at the corrected α-level even when the two potential outliers in the PE + COG group are excluded, F(1,43) = 7.20, p = 0.010. The zero-order correlations also still differed significantly after such outlier removal, Fisher’s Z = 2.67, p = 0.008 (two-tailed).