Figure 3
From: CCN1 promotes hepatic steatosis and inflammation in non-alcoholic steatohepatitis
Upregulation of CCN1 aggravates MCD- or HF-induced hepatic steatosis. (A) Hepatic CCN1 mRNA was detected by qPCR in mice after Ad-GFP or Ad-CCN1 tail vein injection. (B) CCN1 protein was detected by western blotting in mice after Ad-GFP or Ad-CCN1 tail vein injection. (C) H&E staining of liver sections from MCD mice treated with Ad-GFP or Ad-CCN1. (D) Oil red O staining of liver sections from MCD mice treated with Ad-GFP or Ad-CCN1. (E) Statistical analysis of the area of steatosis in liver tissues from MCD mice treated with Ad-GFP or Ad-CCN1. (F) H&E staining of liver sections from HF mice treated with Ad-GFP or Ad-CCN1. (G) Oil red O staining of liver sections from HF mice treated with Ad-GFP or Ad-CCN1. (H) Statistical analysis of the area of steatosis in liver tissues from HF mice treated with Ad-GFP or Ad-CCN1. Statistical significance was assessed by two-tailed Student’s t test. The error bar indicates the SD. *P < 0.05; ***P < 0.001.
