Figure 8
From: CCN1 promotes hepatic steatosis and inflammation in non-alcoholic steatohepatitis
CCN1 aggravates hepatic inflammation and promotes macrophage infiltration during NASH development. (A) Statistical analysis of inflammatory foci in liver tissues from MCD mice treated with Ad-GFP or Ad-CCN1. (B) Statistical analysis of the area of steatosis in liver tissues from MCD mice treated with Ad-shGFP or Ad-shCCN1. (C,D) Representative F4/80 immunohistochemistry from MCD mice treated with Ad-GFP, Ad-CCN1, Ad-shGFP or Ad-shCCN1. (E) Quantification of F4/80-positive cells is shown as the total number of positive cells per field. Statistical significance was assessed by two-tailed Student’s t test. The error bar indicates the SD. *P < 0.05; **P < 0.01.
