Table 2 Genes significantly influenced in hepatocytes by overexpression of the CCN1 gene through microarray analysis.
From: CCN1 promotes hepatic steatosis and inflammation in non-alcoholic steatohepatitis
No. | Gene Symbol | Description | P value | Fold-change | Regulation |
|---|---|---|---|---|---|
1 | Cfd | Complement factor D (adipsin) (Cfd), transcript variant 2 | 0.0015 | 0.3 | down |
2 | Fabp5 | Fatty acid binding protein 5, epidermal (Fabp5), transcript variant 2 | 0.0342 | 0.71 | down |
3 | Sirt3 | Sirtuin 3 (Sirt3), transcript variant 2 | 0.0455 | 1.81 | up |
4 | Acacb | Acetyl-Coenzyme A carboxylase beta (Acacb) | 0.0016 | 2.54 | up |
5 | Cebpd | CCAAT/enhancer binding protein (C/EBP), delta (Cebpd) | 0.044 | 1.97 | up |
6 | Wnt5b | Wingless-type MMTV integration site family, member 5B (Wnt5b), transcript variant 2 | 0.0042 | 2.73 | up |
7 | Cdkn1a | Cyclin-dependent kinase inhibitor 1 A (P21) (Cdkn1a), transcript variant 2 | 0.0003 | 3.4 | up |
8 | Cdkn1b | Cyclin-dependent kinase inhibitor 1B (Cdkn1b) | 0.0149 | 3.04 | up |
9 | Ddit3 | DNA-damage inducible transcript 3 (Ddit3), transcript variant 1 | 0 | 29.35 | up |
10 | Hes1 | Hairy and enhancer of split 1 (Drosophila) (Hes1) | 0.0015 | 1.26 | up |
11 | Sirt1 | Sirtuin 1 (Sirt1), transcript variant 1 | 0.0074 | 2.05 | up |
12 | Sirt2 | Sirtuin 2 (Sirt2), transcript variant 2 | 0.007 | 1.29 | up |
13 | Bmp2 | Bone morphogenetic protein 2 (Bmp2) | 0.0003 | 4.73 | up |
14 | Klf4 | Kruppel-like factor 4 (gut) (Klf4) | 0.0048 | 3.26 | up |
15 | Klf2 | Kruppel-like factor 2 (lung) (Klf2) | 0.007 | 1.82 | up |
16 | Creb1 | cAMP responsive element binding protein 1 (Creb1), transcript variant C | 0.0299 | 1.79 | up |
17 | Nrf1 | Nuclear respiratory factor 1 (Nrf1), transcript variant 1 | 0.0022 | 1.68 | up |
18 | Ppara | Rattus norvegicus peroxisome Proliferator activated receptor alpha (Ppara) | 0.0225 | 1.64 | up |
19 | Wnt5a | Wingless-type MMTV integration site family, member 5A (Wnt5a), transcript variant 2 | 0.0024 | 1.46 | up |
20 | Ncoa2 | Nuclear receptor coactivator 2 (Ncoa2), transcript variant 2 | 0.0199 | 1.52 | up |
21 | Nr1h3 | Nuclear receptor subfamily 1, group H, member 3 (Nr1h3), transcript variant 2 | 0.0111 | 1.4 | up |
22 | Rb1 | Retinoblastoma 1 (Rb1) | 0.0067 | 1.92 | up |
23 | Twist1 | Twist homolog 1 (Drosophila) (Twist1) | 0.0004 | 4.15 | up |
24 | Acat1 | Acetyl-Coenzyme A acetyltransferase 1 (Acat1) | 0.0052 | 2.23 | up |
25 | Acat2 | Acetyl-Coenzyme A acetyltransferase 2 (Acat2) | 0.0271 | 1.27 | up |
26 | Ehhadh | Enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase (Ehhadh) | 0.0009 | 1.77 | up |
27 | Acox2 | Acyl-Coenzyme A oxidase 2, branched chain (Acox2), transcript variant 2 | 0.0008 | 2.18 | up |
28 | Acsl6 | Acyl-CoA synthetase long-chain family member 6 (Acsl6), transcript variant X1 | 0.0282 | 1.6 | up |
29 | Acot2 | Acyl-CoA thioesterase 2 (Acot2) | 0.0062 | 3.02 | up |
30 | Eci2 | Enoyl-Coenzyme A delta isomerase 2 (Eci2), transcript variant 1 | 0.0316 | 1.17 | up |
31 | Klf15 | Kruppel-like factor 15 (Klf15) | 0.0102 | 2.41 | up |
32 | Slc27a3 | Solute carrier family 27 (fatty acid transporter), member 3 (Slc27a3) | 0.0001 | 5.86 | up |
33 | Prkab1 | Protein kinase, AMP-activated, beta 1 non-catalytic subunit (Prkab1) | 0.0176 | 2.1 | up |
34 | Prkab2 | Protein kinase, AMP-activated, beta 2 non-catalytic subunit (Prkab2) | 0.0317 | 1.34 | up |
35 | Prkaca | Protein kinase, cAMP dependent, catalytic, alpha (Prkaca), transcript variant 2 | 0.037 | 1.61 | up |
36 | Prkag2 | Protein kinase, AMP-activated, gamma 2 non-catalytic subunit (Prkag2), transcript variant 2 | 0.0265 | 1.64 | up |
37 | Prkag3 | Protein kinase, AMP-activated, gamma 3 non-catalytic subunit (Prkag3) | 0.0371 | 2.49 | up |
38 | Hmgcl | 3-Hydroxy-3-methylglutaryl-Coenzyme A lyase (Hmgcl) | 0.0419 | 1.37 | up |
39 | Oxct2a | 3-Oxoacid CoA transferase 2A (Oxct2a) | 0.012 | 2.43 | up |
40 | Gpd2 | Glycerol phosphate dehydrogenase 2, mitochondrial (Gpd2), transcript variant 1 | 0.0201 | 1.51 | up |
